NEWS | Past & Present Members
19 April 2022
Kim Quililan is co-author of the paper entitled "Analysis of sub-kilobase chromatin topology reveals nano-scale regulatory interactions with variable dependence on cohesin and CTCF" published recently in Nature Communications. Kim is currently doing her MSc at the International Max Planck Research School for Molecular Biology in Gottingen.
24 March 2022
Vince Arafiles was selected to attend the 71st Lindau Nobel Laureate Meeting. in June 2022.
16 March 2022
Vince Arafiles was awarded the prestigious Alexander von Humboldt fellowship. Vince is currently in Berlin doing his postdoc.
02 March 2022
Carlo Cristobal is first author of the paper entitled "Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin" published today in Journal of Neuroscience. Carlo is currently doing his PhD at Baylor College of Medicine in Texas.
17 February 2022
Shela Algodon and Neos Cruz are co-authors of the paper entitled "Transcriptional Alterations in X-Linked Dystonia–Parkinsonism Caused by the SVA Retrotransposon" published today in the International Journal of Molecular Sciences. Shela is currently a PhD student in Lubeck while Neos is an MSc student in Gottingen.
04 February 2022
Josh Danac was offered an MRes+PhD scholarship at the University of Cambridge where he will be studying Cancer Biology at the Cancer Research UK (CRUK) Cambridge Center. Kim Quililan was offered a scholarship and will be doing her PhD at the world-renowned Francis Crick Institute in London. She was also offered a PhD scholarship by the University of Oxford but chose Crick instead.
02 February 2022
Dr. Che Tumampo successfully defended her PhD thesis enitled “Functional Characterization of the Novel Oncogenic RRAS mutants p.P25L, p.N111= and p.D134N identified in Filipino Colorectal Cancer Patients”. This is part of the MD-PhD program at the University of the Philippines College of Medicine.
31 January 2022
Our undergraduate thesis students—Paeng Ambag and Andrei David—are 2021's recipients of the prestigious Ed Padlan Awards (given to the top 2 students at the end of their junior year).
24 Janaury 2022
J-Ann Marie Lego successfully defended her thesis Master's thesis entitled "Investigation on the microRNA-mediated regulation of the long non-coding RNA HULC in colorectal cancer cells:.
20 January 2022
Vince Arafiles is co-author of the paper entitled "Artificial Nanocage Formed via Self-Assembly of β-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors" published in the journal Bioconjugate Chemistry.
12 January 2022
Joseph Neos is co-author of the review entitled "X-linked dystonia-parkinsonism: over and above a repeat disorder": published in the journal Medizinische Genetik. Neos is currently doing his MSc at the International Max Planck Research School for Molecular Biology in Gottingen, Germany.
27 December 2021
Jan Vincent Arafiles is co-author of the paper entitled "Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein–Protein Interactions on a Cell-Penetrating Peptide Scaffold" published in the journal Molecular Pharmaceutics.
11 December 2021
Arlou Angeles is first author of a paper published this week in NPJ Precision Oncology, entitled "Early identification of disease progression in ALK-rearranged lung cancer using circulating tumor DNA analysis". Arlou is currently doing her postdoc at DKFZ, Heidelberg.
03 December 2021
DMBEL alumnus Paulo Lorenzo, the lab's first RA, successfully defended his PhD thesis today (magna cum laude) at the German Cancer Research Center (DKFZ) / University of Heidelberg. CONGRATULATIONS!
02 December 2021
The lab's 5th peer-reviewed paper for the year was accepted for publication by the journal Cells (IF: 6.6): "The novel phosphatase domain mutations Q171R and Y65S switch PTEN from tumor suppressor to oncogene".
26 November 2021
Lorenz Chua (currently finishing his PhD in Berlin) is co-author of a paper on SARS-CoV-2 published in Cell entitled "SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis".
23 November 2021
Dr. Arlou Angeles [currently doing her postdoc at the German Cancer Research Center (DKFZ) in Heidelberg] is co-first author of a review published recently in Cancers: "Liquid Biopsies beyond Mutation Calling: Genomic and Epigenomic Features of Cell-Free DNA in Cancer".
17 November 2021
Andrea Salvador is co-author of the paper "GABAergic neuronal IL-4R mediates T cell effect on memory" published yesterday in Neuron. Andrea is currently doing her PhD at the University of Virginia and Washington University in St. Louis.
11 November 2021
DMBEL alumnus Dr. Jian Kenzo Leal ranked #2 in the November 2021 Physician Licensure Exams.
03 November 2021
Carlo Cristobal, currently doing his PhD at Baylor College of Medicine, is co-author of the paper "Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function" published recently in EMBO Rep.
29 October 2021
DMBEL alumnus, Lorenz Chua, is co-author of a paper published in the journal Nature, entitled "Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells".
26 October 2021
DMBEL is featured in the College of Science website as part of the "Science, Technology and Society" month celebrations this October. Our research interests, as well as the volunteer work done by members of the lab in the early months of the pandemic, were highlighted. Click here for the link.
19 October 2021
The lab's PI, Dr. Rey Garcia, was awarded a University of the Philippines Centennial Professorial Chair for 2021.
15 September 2021
Our latest paper entitled "Concomitant and decoupled effects of cigarette smoke and SCAL1 upregulation on oncogenic phenotypes and ROS detoxification in lung adenocarcinoma cells" (Carmela Cruz, Jolo Ferrer & Rey Garcia) is out today in Scientific Reports.
14 September 2021
Chuck Bataclan co-authored a review published recently in Best Practice & Research Clinical Endocrinology & Metabolism entitled "Bone marrow adiposity and the hematopoietic niche: A historical perspective of reciprocity, heterogeneity, and lineage commitment". Chuck is currently doing his PhD at the University of Lausanne.
Marian Abigaile Manongdo-Bataclan is co-author of a review entitled "RNA-binding proteins and RNA methylation in myeloid cells" published in Immunological Reviews. Yana is doing her PhD at the Institute for Research in Biomedicine / ETH Zürich.
01 September 2021
Martin Qui is co-author of the paper entitled "Rapid measurement of SARS-CoV-2 spike T cells in whole blood from vaccinated and naturally infected individuals", published in The Journal of Clinical Investigation. Martin is currently doing his MD-PhD at Duke-NUS Medical School.
01 September 2021
Martin Qui is co-author of a review entitled "SARS-CoV-2-specific T cells in infection and vaccination", published in Cellular & Molecular Immunology.
20 August 2021
Lorenz Chua is co-author of a paper in NATURE BIOTECHNOLOGY entitled "Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children". Lorenz is currently in Berlin doing his PhD.
15 August 2021
Aeiou Martija authored a review entitled "The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma" in MDPI's International Journal of Molecular Sciences. Aeiou is doing his PhD at the DKFZ in Heidelberg.
08 July 2021
Arman Ghodsinia was offered an MRes + PhD scholarship (Cancer Biology) at the University of Cambridge. He will be doing his studies at the Cancer Research UK Cambridge Institute and will be affiliated with Trinity College.
21 June 2021
Lorenz Chua is co-author of a paper published this week in Nature Communications entitled "SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals". Lorenz is currently finishing his PhD in Berlin.
05 June 2021
Jana Quismundo is co-author of a paper entitled "Identifying genetic modifiers of age-associated penetrance in X-linked dystonia-parkinsonism" published in NATURE COMMUNICATIONS. This is from her work as an intern at the Institute of Neurogenetics, University of Lubeck, in the lab of Dr. Christine Klein. Jana is currently doing a joint Master's degree (Berlin and Amsterdam) on a Neurasmus scholarship.
03 June 2021
The National Academy of Science and Technology (NAST) has chosen our team's 5-volume book entitled "Tuklas Lunas Protocols for Drug Discovery and Development" (Dr. Rita Alvero and Dr. Amelia Guevara, eds.) as recipient of the 2021 OUTSTANDING BOOK AND/OR MONOGRAPH AWARD. The lab contributed the entire Manual 2C (Orthogonal and Secondary Assays), almost half of Manual 2B (primary assays) and a third of Manual 2A (Safety Tests).
01 June 2021
Charles John Uy was offered a PhD position at the Olivia Newton-John Cancer Research Institute (ONJCRI) in Melbourne. ONJCRI houses the world-class Ludwig Institute for Cancer Research.
25 May 2021
Martin Qui is co-author of an article entitled "A Virus-Specific Immune Rheostat in the Immunome of Patients Recovering From Mild COVID-19", published in Frontiers in Immunology.
28 April 2021
Vince Arafiles, who just moved to Berlin for his postdoc, has a new co-authored paper published in the journal Chemical Science. The paper, entitled "A facile combinatorial approach to construct a ratiometric fluorescent sensor: application for the real-time sensing of cellular pH changes", is an output of his former lab in Kyoto.
Shela Algodon has been offered a PhD position at the Institute of Neurogenetics, University of Lubeck in Germany. She will be working on X-linked Dystonia Parkinsonism..
Andrea Salvador is co-author of a paper published in Nature by their lab in Virginia, entitled "Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy".
20 April 2021
Kenneth Anthony Roquid, currently doing his PhD at the International Max Planck Research School for Heart and Lung Research in Germany, is co-author of the paper entitled "GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis" published this week in PNAS.
14 April 2021
Our paper entitled "CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity" (Joshua Miguel C. Danac and Reynaldo L. Garcia) was accepted for publication by the journal Scientific Reports.
09 April 2021
Martin Qui is co-first author of a paper published in Med (a Cell Press journal) entitled "Early T cell and binding antibody responses are associated with Covid-19 RNA vaccine efficacy onset". Martin is currently an MD-PhD scholar at the Duke-NUS Medical School.
07 April 2021
Jan Vincent Arafiles is co-author of a new paper published recently in Bioorganic and Medicinal Chemistry Letters, entitled " Use of homoarginine to obtain attenuated cationic membrane lytic peptides". Vince just moved to Berlin from Kyoto to start a postdoctoral fellowship.
04 April 2021
J-Ann Marie Lego was offered a 3-month internship by the Dresden International Graduate School for Biomedicine and Bioengineering in Germany. She will be working in the laboratory of Dr. Anthony Gavalas, an expert in stem cell biology and regenerative medicine. Because of the pandemic, J-Ann will be in Germany from September-November, instead of July to September.
03 April 2021
Our review, entitled "Exosomal microRNAs in colorectal cancer: overcoming barriers of the metastatic cascade" (Joshua Miguel C. Danac, Aileen Geobee G. Uy and Reynaldo L. Garcia), has been accepted for publication in the International Journal of Molecular Medicine.
30 March 2021
Bea Demigillo and Aileen Uy were both offered an Erasmus Mundus Joint Master's Degree (fully funded) scholarship (Innovative Medicine Program). Both of them will be at the University of Heidelberg in Germany during their first year. Bea will then move to the University of Groningen in The Netherlands, and Aileen to Uppsala University in Sweden, for their second year.
22 March 2021
Kate Co was honored as one of this year's two Ed Padlan awardees. The award honors the achievements of Dr. Ed Padlan, a US-based Filipino scientist known internationally for his pioneering work in antibody engineering. The award is given to the top 2 undergraduates of the NIMBB at the start of their senior year. Kate is the lab's 9th recipient of the prestigious award.
04 March 2021
Lorenz Chua is co-author of a paper on single cell mRNA sequencing of patient-derived colorectal cancer cultures entitled "Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer", published in the journal Cancers. Lorenz is currently in Berlin finishing his PhD.
02 March 2021
Andrea Salvador is first author of a review published yesterday in Nature Reviews Immunology, entitled "Neuromodulation by the immune system: a focus on cytokines". Andrea is currently doing her PhD at the University of Virginia.
01 March 2021
Our paper entitled "Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer" (Dennis Lee Sacdalan, Reynaldo L. Garcia et al) is out today in Cancer Management and Research.
25 February 2021
Krizelle Alcantara, was a speaker at the 4th Annual GENE THERAPY FOR RARE DISORDERS Conference in the US (Feb 22-25, 2021; 100% Digital this year because of the pandemic). Krizelle is currently with the Center for Gene Therapy of the Abigail Wexner Research Institute at Nationwide Children’s Hospital in Columbus, Ohio, USA.
24 February 2021
Vince Arafiles is first author of a paper published today in Angewandte Chemie (A Journal of the German Chemical Society), entitled "Discovery of a Macropinocytosis‐Inducing Peptide Potentiated by Medium‐Mediated Intramolecular Disulfide Formation". Vince will soon be moving from Kyoto to Berlin to take up a postdoctoral fellowship.
20 February 2021
Neos Cruz has been offered a scholarship in the MSc/PhD program of the International Max Planck Research School for Molecular Biology in Gottingen, Germany. No final decision yet from Neos though since he is also shortlisted for various other scholarships.
18 February 2021
Liezel Tamon is co-author of a paper published today in Angewandte Chemie (A Journal of the German Chemical Society), entitled "Thermal and pH stabilities of i‐DNA: confronting in vitro experiments with models and in‐cell NMR data". Liezel is currently doing her PhD at Oxford University.
27 January 2021
Andrea Salvador is co-author of a paper published in CELL: "Functional characterization of the dural sinuses as a neuroimmune interface". Andrea is doing her PhD at the University of Virginia.
January 27 2021
Brandon Sy's review entitled "Small RNA Regulation of Virulence in Pathogenic Escherichia coli" was published today in Frontiers in Cellular and Infection Microbiology. Brandon is currently doing his postdoc at the University of New South Wales.
24 December 2020
Lorenz Chua is co-first author of another paper on COVID-19 published in Nature Biotechnology. Lorenz is currently in Berlin doing his PhD. Check out the paper via this link: "Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19".
11 December 2020
Carlo Cristobal is first author of a paper in Journal of Cell Science, entitled "Daam2 couples translocation and clustering of Wnt receptor signalosomes through Rac1". Carlo is currently a PhD student at Baylor College of Medicine. The paper is now online, published ahead of print.
03 December 2020
Kenneth Anthony Roquid is co-author of a paper published in JCI (Journal of Clinical Investigation) Insight, entitled "Disturbed flow–induced Gs-mediated signaling protects against endothelial inflammation and atherosclerosis". Kenneth is currently doing his PhD at the Max Planck Institute for Heart and Lung Research in Germany.
30 November 2020
Lorenz Chua, currently doing his PhD in Berlin, is co-author of a paper published today in Nature Neuroscience, entitled "Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19",
20 November 2020
Arlou Angeles, currently doing her postdoc at DKFZ in Heidelberg, is co-author of a paper entitled "Longitudinal therapy monitoring of ALK-positive lung cancer by combined copy number and targeted mutation profiling of cell-free DNA", now online ahead of print in EBioMedicine (published by The Lancet).
06 November 2020
Dennis Lee Sacdalan, MD, is senior author of a review article published this week in the journal Medical Oncology: "Beyond bevacizumab: a review of targeted agents in metastatic small bowel adenocarcinoma".
28 October 2020
Krizelle Alcantara just gave a presentation at the 4th Annual Gene Therapy for Rare Diseases (Europe) Conference. The lab is proud that Krizelle is able to do pioneering work on gene therapy of neurofibromatosis 2 (NF2) with their team at Ohio State University. As both NF2 researcher and NF2 patient, Krizelle's sense of mission and rectitude of intention are unquestionable and awe-inspiring. She has pursued NF2 research from her BSc and MSc theses in our lab through to her current work in the US. Her mission is to #EndNF2.
21 October 2020
Dr. Dennis Sacdalan, who is an oncologist finishing up his PhD in the lab, is senior author of a paper entitled "Patterns of Biomarker Use in Cancer Treatment Among Medical Oncologists in the Philippines", published in JCO Global Oncology.
19 October 2020
Rey Garcia, principal investigator of the laboratory, was awarded a University of the Philippines Centennial Professorial Chair.
13 October 2020
Joseph Neos Cruz left the lab to do a 10-month research internship at the University of Lubeck in Germany. He will be joining a research group working on X-linked Dystonia Parkinsonism.
09 October 2020
Liezel Tamon, currently doing her PhD at Oxford University, is co-author of a paper entitled "RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk", published in CELL DEATH AND DIFFERENTIATION. This is from her MSc work back in IMPRS Gottingen.
02 October 2020
Pao Aguilar MD (currently also an MSc student in the lab) passed the physician licensure examinations (medical boards). Congratulations!
30 September 2020
Carlo Cristobal, currently doing his PhD at Baylor College of Medicine, is co-first author of a paper recently published in Biomaterials: "Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury".
25 September 2020
Brandon Sy, PhD, recently published a paper out of his PhD thesis at the University of New South Wales, in PNAS. Click on this title to access the link: "Early termination of the Shiga toxin transcript generates a regulatory small RNA".
15 September 2020
Andrea Salvador, currently doing her PhD at the University of Virginia, is co-author of a paper published in Nature Immunology. Click on this title to access the link: "Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons".
13 September 2020
Vince Arafiles, PhD, is co-author of a review article published recently in Chemistry Letters. Click on this title to access the link: "Peptide-assisted Intracellular Delivery of Biomacromolecules".
10 September 2020
Arman Ghodsinia finished his MSc in Radiation Biology at the MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, WITH DISTINCTION. Arman was a recipient of the prestigious Chevening scholarship while at Oxford.
8 September 2020
Anton Garrido successfully defended his MSc thesis entitled "Phenotypic characterization of the novel PTEN mutants Q171R and Y65S identified from Filipino colorectal cancer patients". He will soon take up his PhD scholarship at the University of Nevada in Las Vegas.
4 September 2020
Three former members of the lab recently finished their graduate studies: Vince Arafiles, PhD in Pharmaceutical Sciences from Kyoto University; Andrea Ong, MPhil in Bioscience Enterprise from the University of Cambridge; and Abi Hilario, Master's in Biotechnology at the University of Queensland.
1 September 2020
Carlo Cristobal, currently doing his PhD at Baylor College of Medicine, is co-author of a paper recently published in Genes & Development. Click on this title to access the link: "The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation".
17 August 2020
Arlou Angeles, Dr. rer. nat., recently published a paper from her PhD thesis at DKFZ (German Cancer Research Center, Heidelberg) in the journal Molecular Cancer Research. Click on this title to access the link: "The ERG-Regulated LINC00920 Promotes Prostate Cancer Cell Survival via the 14-3-3ε–FOXO Pathway"
16 August 2020
Nori Galang left the laboratory to take up an MSc scholarship at Radboud University in the Netherlands. Earlier, another member of the lab, Kim Quililan, also left to take up a research internship at the Center for Genomic Regulation in Barcelona. Kim will start her MSc/PhD in September at the International Max Planck Research School for Molecular Biology in Goettingen, Germany.
21 July 2020
Ryan Lim and Chloe Borromeo graduated valedictorian and salutatorian of MBB Class of 2020, respectively. Ryan is also the batch valedictorian of the College of Science.
14 July 2020
Tiffany Ong recently published a paper out of her MSc thesis at the National University of Singapore in the journal Frontiers in Bioengineering and Biotechnology. Click on this title to access the link: "pHLuc, a Ratiometric Luminescent Reporter for in vivo Monitoring of Tumor Acidosis".
3 July 2020
Ryan Yu's paper is out today in Scientific Reports. This work was Ryan's undergraduate thesis which he continued working on while working as an RA in the lab. Click on this title to access the link: "NRAS mutant E132K identifed in young‑onset sporadic colorectal cancer and the canonical mutants G12D and Q61K affect distinct oncogenic phenotypes". A blog-type summary for the Nature Research Cancer Community accompanies the article. Kindly click on this title to access the link: "Delineating the differential phenotypic readouts of novel and canonical colorectal cancer NRAS and KRAS mutants".
26 June 2020
Lorenz Chua, who is currently a PhD student in Berlin, is first among co-first authors in a COVID-19 paper published in Nature Biotechnology. Click on this title to access the link: "COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis".
Brandon Sy, PhD, is co-author in a paper published recently in eLife entitled "Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation". Brandon is currently a postdoc at the University of New South Wales.
30 April 2020
The paper of Arman Ghodsinia and J-Ann Lego is out today in Cells. The paper started as Arman's undergraduate thesis which he continued working on while working as an RA in the lab. Click on this title to access the link: "Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants".
9 April 2020
Lorenz Chua is co-first author in a COVID-19 paper published in The EMBO Journal. Lorenz is currently doing his PhD at Charite and the Berlin Institute of Health. Click on this title to access the link: "SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells."
5 February 2020
Vince Arafiles, currently a final year PhD student at Kyoto University, is first author of a paper published recently in Bioconjugate Chemistry. Click on this title to access the link: "Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides To Facilitate Endosomal Escape".
1 February 2020
The paper of Kenneth Anthony Roquid and Krizelle Alcantara, entitled "Identification and validation of mRNA 3'untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN", is out now in the Feb 2020 issue of the International Journal of Oncology. This paper started as Kenneth's undergraduate thesis in the lab, which he continued working on for his MSc thesis.
While the university and the entire Metro Manila were on lockdown, 11 members of the laboratory volunteered to help with RT-qPCR/COVID-19 testing: Marlon Echavez, Day Olivar-Echavez, and JM Sytangco at the Research Institute for Tropical Medicine; Jolo Ferrer, Mickai Leano, Allen de Borja, Josh Danac, Neos Cruz, and Nori Galang at the Lung Center of the Philippines; Avvin Pelovello at the UP National Institutes of Health; and J-Ann Lego at the Philippine Genome Center. Other members of the laboratory led by Josh Danac and Isay Viola, also helped with mapping and loaning out of qPCR machines to laboratories, mobilization of testing volunteers, donation and information campaigns, and procurement. The lab also made available to the Lung Center of the Philippines many pieces of equipment, lab consumables and reagents: from qPCR machine, biosafety cabinet, centrifuge, pipette sets, multichannel pipettors; through to filtered tips, PCR plates, and other items.